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Publications
NITD Publications
2008
  • Li, Xiaojin; Manjunatha, Ujjini H.; Goodwin, Michael B.; Knox, John E.; Lipinski, Christopher A.; Keller, Thomas H.; Barry, Clifton E., III; Dowd, Cynthia S. Synthesis and antitubercular activity of 7-(R)- and 7-(S)-methyl-2-nitro-6-(S)-(4-(trifluoromethoxy)benzyloxy)-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazines, analogues of PA-824. Bioorganic & Medicinal Chemistry Letters (2008), 18(7), 2256-2262.
  • Matter, Alex; Keller, Thomas H. Impact of non-profit organizations on drug discovery: opportunities, gaps, solutions. Drug Discovery Today (2008), 13(7-8), 347-52.
  • Rao, Srinivasa PS; Camacho, Luis; Huat Tan Bee; Boon, Calvin; Russel, David G; Dick, Thomas; Pethe, Kevin. Recombinase-based reporter system and antisense technology to study gene expression and essentiality in hypoxic nonreplicating mycobacteria. FEMS Microbiology Letters (2008), 284(1), 68-75.
  • Luo, Dahai; Xu, Ting; Hunke, Cornelia; Gruber, Gerhard; Vasudevan, Subhash G.; Lescar, Julien. Crystal structure of the NS3 protease-helicase from dengue virus. Journal of Virology (2008), 82(1), 173-183.
  • Tanner, Lukas; Schreiber, Mark; Low, Jenny GH; Ong Adrian; Tolfvenstam, Thomas; Lai Yee Ling; Ng Lee Ching; Leo Yee Sin; Thi Puong Le; Vasudevan, Subhash G.; Simmons, Cameron P; Hibberd, Martin L; Ooi Eng Eong. Decision tree algorithms predict the diagnosis and outcome of dengue Fever in the early phase of illness. PLoS Neglected Tropical Diseases (2008), 2(3), e196.
  • Ong Swee Hoe; Yip Jin Teen; Chen Yen-Liang; Liu Wei; Harun Syahrial; Lystiyaningsih Erlin; Heriyanto Bambang; Beckett, Charmagne G; Mitchell, Wayne P; Hibberd, Martin L; Suwandono Agus; Vasudevan, Subhash G; Schreiber, Mark J. Periodic re-emergence of endemic strains with strong epidemic potential - a proposed explanation for the 2004 Indonesian dengue epidemic. Infect Genet Evol. (2008), 8(2), 191-204.
2007
  • Shui, Guanghou; Bendt, Anne K.; Pethe, Kevin; Dick, Thomas; Wenk, Markus R. Sensitive profiling of chemically diverse bioactive lipids. Journal of Lipid Research (2007), 48(9), 1976-1984.
  • Fink, Joshua; Gu, Feng; Ling, Ling; Tolfvenstam, Thomas; Olfat, Farzad; Chin, Keh Chuang; Aw, Pauline; George, Joshy; Kuznetsov, Vladimir A.; Schreiber, Mark; Vasudevan, Subhash G.; Hibberd, Martin L. Host gene expression profiling of dengue virus infection in cell lines and patients. PLoS Neglected Tropical Diseases (2007), 1(2), e86.
  • Umareddy, Indira; Pluquet, Olivier; Wang, Qing Yin; Vasudevan, Subhash G.; Chevet, Eric; Gu, Feng. Dengue virus serotype infection specifies the activation of the unfolded protein response. Virology Journal (2007), 4:91
  • Ng, Chuan Young; Gu, Feng; Phong, Wai Yee; Chen, Yen-Liang; Lim, Siew Pheng; Davidson, Andrew; Vasudevan, Subhash G. Construction and characterization of a stable subgenomic dengue virus type 2 replicon system for antiviral compound and siRNA testing. Antiviral Research (2007), 76(3), 222-231.
  • Löhr, Kristina; Knox, John E.; Phong, Wai Yee; Ma, Ngai Ling; Yin, Zheng; Sampath, Aruna; Patel, Sejal J; Wang, Wei-Ling; Chan, Wai-Ling, Rao, KR; Wang, Gang; Vasudevan, Subhash G; Keller, Thomas H.; Lim, Siew Pheng. Yellow fever virus NS3 protease: peptide-inhibition studies. J Gen Virol. (2007), 88(8):2223-7.
  • Pryor, Melinda J.; Rawlison Stephen M.; Butcher, Rebecca E.; Barton, Chenoa L.; Waterhouse, Tracey A.; Vasudevan, Subhash G.; Bardin, Philip G.; Wright, Peter J.; Jans, David A.; Davidson, Andrew D. Nuclear Localization of Dengue Virus Nonstructural Protein 5 Through Its Importin alpha/beta-Recognized Nuclear Localization Sequences is Integral to Viral Infection. Traffic. (2007), 8(7):795-807.
  • Schreiber, Mark J.; Ong, Swee Hoe; Holland, Richard C.; Hibberd, Martin L.; Vasudevan, Subhash G.; Mitchell WP; Holmes, Edward C. DengueInfo: A web portal to dengue information resources. Infect Genet Evol. (2007), 7(4):540-541.
  • Schul, Walter; Liu, Wei; Xu, Haoying; Flamand, Marie; Vasudevan, Subhash G. A dengue fever viremia model in mice shows reduction in viral replication and suppression of the inflammatory response after treatment with antiviral drugs. J Infect Dis. (2007), 195(5):665-674.
  • Yap, Thai Leong; Xu, Ting; Chen, Yen-Liang; Malet, Helene; Egloff, Marie-Pierre; Canard, Bruno; Vasudevan, Subhash G.; Lescar, Julien. Crystal structure of the dengue virus RNA-dependent RNA polymerase catalytic domain at 1.85-angstrom resolution. Journal of Virology (2007), 81(9):4753-4765.
  • Yap, Thai Leong; Chen, Yen-Liang; Xu, Ting; Wen, Daying; Vasudevan, Subhash G.; Lescar, Julien. A multi-step strategy to obtain crystals of the dengue virus RNA-dependent RNA polymerase that diffract to high resolution. Acta Crystallographica, Section F: Structural Biology and Crystallization Communications (2007), F63(2): 78-83.
2006
  • Low, Jenny GH; Ooi, Eng-Eong; Tolfvenstam, Thomas; Leo, Yee-Sin; Hibberd, Martin L; Ng, Lee-Ching; Lai, Yee-Ling; Yap, Grace SL; Li, Chenny SC; Vasudevan, Subhash G; Ong, Adrian Early Dengue infection and outcome study (EDEN) - study design and preliminary findings. Ann Acad Med Singapore (2006), 35(11):783-9.
  • Teo, Jeanette WP; Thayalan, Pamela; Beer, David; Yap, Amelia SL; Nanjundappa, Mahesh; Ngew, Xinyi; Duraiswamy, Jeyaraj; Liung, Sarah; Dartois, Veronique; Schreiber, Mark; Hasan, Samiul; Cynamon, Michael; Ryder, Neil S.; Yang, Xia; Weidmann, Beat; Bracken, Kathryn; Dick, Thomas; Mukherjee, Kakoli. Peptide deformylase inhibitors as potent antimycobacterial agents. Antimicrobial Agents and Chemotherapy (2006), 50(11):3665-3673.
  • Knox, John E.; Ma, Ngai Ling; Yin, Zheng; Patel, Sejal J.; Wang, Wei-Ling; Chan, Wai-Ling; Rao, K. R. Ranga; Wang, Gang; Ngew, Xinyi; Patel, Viral; Beer, David; Lim, Siew Pheng; Vasudevan, Subhash G.; Keller, Thomas H.. Peptide Inhibitors of West Nile NS3 Protease: SAR Study of Tetrapeptide Aldehyde Inhibitors. Journal of Medicinal Chemistry (2006), 49(22):6585-6590.
  • Hasan, Samiul; Daugelat, Sabine; Rao, P. S. Srinivasa; Schreiber, Mark. Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis. PLoS Computational Biology (2006), 2(6):539-550.
  • Hibberd, Martin L.; Ling Ling; Tolfvenstam, Thomas; Mitchell, Wayne; Wong C; Kuznetsov, Vladimir A.; George, Joshy; Ong Swee Hoe; Ruan Yijuan; Wei Chia Ling; Gu Feng; Fink, Joshua; Yip Andy; Liu Wei; Schreiber, Mark; Vasudevan, Subhash G. A genomics approach to understanding host response during dengue infection. Novartis Foundation Symposium (2006), 277:206-14.
  • Keller, Thomas H.; Chen, Yen Liang; Knox, John E.; Lim, Siew Pheng; Ma, Lai Ngai; Patel Sejal J; Sampath, Aruna; Wang, Qing Yin; Yin, Zheng; Vasudevan Subhash G. Finding new medicines for flaviviral targets. Novartis Foundation Symposium (2006), 277:102-114.
  • Xu, Ting; Sampath, Aruna; Chao, Alex; Wen, Daying; Nanao, M; Luo, D; Chene, P; Vasudevan, Subhash G; Lescar, Julien. Towards the design of flavivirus helicase/NTPase inhibitors: crystallographic and mutagenesis studies of the dengue virus NS3 helicase catalytic domain. Novartis Foundation Symposium (2006), 277 (New treatment strategies for dengue and other flaviviral diseases), 87-97.
  • Umareddy, Indira; Chao, Alex; Sampath, Aruna; Gu, Feng; Vasudevan, Subhash G. Dengue virus NS4B interacts with NS3 and dissociates it from single-stranded RNA. Journal of General Virology (2006), 87(9):2605-2614.
  • Keller, Thomas H.; Pichota, Arkadius; Yin, Zheng. A practical view of 'druggability'. Current Opinion in Chemical Biology (2006), 10(4):357-361.
  • Sampath, Aruna; Xu, Ting; Chao, Alex; Luo, Dahai; Lescar, Julien; Vasudevan, Subhash G. Structure-based mutational analysis of the NS3 helicase from dengue virus. Journal of Virology (2006), 80(13):6686-6690.
  • Hasan, Samiul; Schreiber, Mark J. Recovering motifs from biased genomes: application of signal correction. Nucleic Acids Research (2006), 34(18), 5124-5132.
  • Manjunatha, Ujjini H.; Boshoff, Helena; Dowd, Cynthia S.; Zhang, Liang; Albert, Thomas J.; Norton, Jason E.; Daniels, Lacy; Dick, Thomas; Pang, Siew Siew; Barry, Clifton E., III. Identification of a nitroimidazo-oxazine-specific protein involved in PA-824 resistance in Mycobacterium tuberculosis. Proceedings of the National Academy of Sciences of the United States of America (2006), 103(2):431-436.
  • Fink, Joshua; Feng, Gu; Vasudevan, Subhash G. Role of T cells, cytokines and antibody in dengue fever and dengue haemorrhagic fever. Reviews in Medical Virology (2006), 21(16):263-275.
  • Erbel, Paul; Schiering, Nikolaus; D'Arcy, Allan; Renatus, Martin; Kroemer, Markus; Lim, Siew Pheng; Yin, Zheng; Keller, Thomas H.; Vasudevan, Subhash G.; Hommel, Ulrich. Structural basis for the activation of flaviviral NS3 proteases from dengue and West Nile virus. Nature Structural & Molecular Biology (2006), 13(4):372-373.
  • Yin, Zheng; Patel, Sejal J.; Wang, Wei-Ling; Chan, Wai-Ling; Ranga Rao, K. R.; Wang, Gang; Ngew, Xinyi; Patel, Viral; Beer, David; Knox, John E.; Ma, Ngai Ling; Ehrhardt, Claus; Lim, Siew Pheng; Vasudevan, Subhash G.; Keller, Thomas H. Peptide inhibitors of dengue virus NS3 protease. Part 2: SAR study of tetrapeptide aldehyde inhibitors. Bioorganic & Medicinal Chemistry Letters (2006), 16(1):40-43.
  • Yin, Zheng; Patel, Sejal J.; Wang, Wei-Ling; Wang, Gang; Chan, Wai-Ling; Rao, K. R. Ranga; Alam, Jenefer; Jeyaraj, Duraiswamy A.; Ngew, Xinyi; Patel, Viral; Beer, David; Lim, Siew Pheng; Vasudevan, Subhash G.; Keller, Thomas H. Peptide inhibitors of dengue virus NS3 protease. Part 1: Warhead. Bioorganic & Medicinal Chemistry Letters (2006), 16(1):36-39.
2005
  • Xu, Ting; Sampath, Aruna; Chao, Alex; Wen, Daying; Nanao, Max; Chene, Patrick; Vasudevan, Subhash G.; Lescar, Julien. Structure of the Dengue virus helicase/nucleoside triphosphatase catalytic domain at a resolution of 2.4Å Journal of Virology (2005), 79(16):10278-10288.
  • Li, Jun; Lim, Siew Pheng; Beer, David; Patel, Viral; Wen, Daying; Tumanut, Christine; Tully, David C.; Williams, Jennifer A.; Jiricek, Jan; Priestle, John P.; Harris, Jennifer L.; Vasudevan, Subhash G. Functional Profiling of Recombinant NS3 Proteases from All Four Serotypes of Dengue Virus Using Tetrapeptide and Octapeptide Substrate Libraries. Journal of Biological Chemistry (2005), 280(31):28766-28774.
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